We have observed in experimental animal model, those are pigs. That is when animal models are under stress, their blood cells becomes echinotic shape leaving the discoid shape. When the stress and mental status change, this scenario keeps repeating in animals & human which leads to physiological changes with pathological manifestation. Repetition of this conditions is causing the mutations, brings errors in metabolic pathways, causing the protein to be faulty. In the process of translation, the entire immune system of human is disturbed.. This whole process makes the macrophages to be inactive, allows further deposition of intracellular Calcium, lipids leading to partial or complete blockages in arterial system depriving mitochondria from oxygenation.

        We have learnt from the experimental studies reversing the metabolic process by the de-mutation cannot alone remove the deposits. Unless the macrophages become active by quality & quantity which engulfs the deposited molecules, one by one taking it to liver for degradation, which ultimately excretes through bile. This is the normal scenario of removal of the plaques leaving the arterial tree free of blockages.I describe DNA is acting as a commander which commands the order to be executed by m-RNA. Usually, m-RNA carry out the order and occasionally, it does not such as in case of silent mutations. However, m-RNA requires ammunitions to execute the order given by DNA. M-RNA manufacture its own ammunitions such as structurally active amino acids, which are behaving like cargo proteins sending to respective sites for mental and physical development of the individual curing the disease permanently by reversing the metabolic processes and in worst conditions, it causes the incurable diseases leading to extensive suffering of the individual and premature death.

        The manufacturing of ammunition or new protein takes place in ribosomes, which is called as a factory, where t-RNA comes to contribute its part and then transported to golgi, which is transported to required site for its individual function. It may not be transported and if it does not, this protein cannot be active. Thus the final result may be beneficial or detrimental.

         Last condition is due to mutation of that particular gene and when the disease is cured by reversing the metabolic process, which is done by demutation of that gene.

         Our genetic research work has compelled us to make an announcement with confirmation that mutation of incurable diseases takes place at the age between 13-16 while physiological changes takes place in the individual and expressed clinically in a particular disease form, in which that mutation has taken place, which may require 20-25years. Now, we have young volunteers between 13-16 having mutations of the gene,,,,,,,, which will expressed in coronary artery disease in another 20 years. We have cleared the mutation and eradicate the risks of having coronary artery disease of these volunteers by injecting the Baruah biological molecules, which engineered the mutated genes by reversing the metabolic processes and cleared them permanently from these dreaded diseases. By using these technique timely which was not thought in the past, we can eradicate completely the heart diseases, diabetes, hypertension and cancer.

         Bypass surgery is a genetically mismatch, harmful and criminal surgical procedure. The process of harmness begins from the day of the bypass surgery, which is expressed phenotypically in no time. The bypass surgery is a larger stimulus for signal transduction with larger effect expressed phenotypically which gives premature death to the individual.