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M anifestation
of Baruah syndromE
Moyamoya- is a misnomer
Moyamoya disease is a
rare, progressive cerebrovascular genetic disorder.
Cerebral angiography has shown blockages of internal
carotid artery at the site of entry into brain and
accidently, blood supply to the brain is made by
enormous collateral circulation giving the appearance of
puff of smoke. It is first described in Japan in 1960s,
and since been found in the United States, Europe,
Australia, and Africa. It primarily affects children,
adolescents, and young adults, although it has also been
seen in people beyond these ages. Females are more
frequently affected than males. The cause of the disease
was unknown. Researchers suspect a genetic link because
of the high incidence of the disease found in certain
Japanese families.
Our studies in recent
years on genetic engineering has revealed the following
about this dreaded disease-
 It
is due to mistake in DNA
This occurs in
children and adults as well.
Metabolic disorder-
Although the Japanese founder of the disease has named
it as moyamoya (moya means tiny), he could not find or
describe the mechanism of biochemical process, how these
blockages occur inside the cranium. He only described
the ultimate effect of it.
 I have named it as
dhuan-dhuan (Cloud of smoke)
Our studies have
suggested that excessive accumulation of intracellular
calcium due to mistake in DNA causes this disease
leading to the atrophy of the tissue and premature
death. Before death, patient will have several fainting
attacks, physical weakness, paralysis . But the fact
remains, the death is certain prematurely.
In children, the
first symptom of Moyamoya disease is often stroke, or
recurrent transient ischemic attacks (TIA, commonly
referred to as "mini-strokes"), frequently accompanied
by muscular weakness or paralysis affecting one side of
the body, or seizures.
Adults most often
experience a hemorrhagic stroke due to recurring blood
clots in the affected brain vessels. Individuals with
this disorder may have disturbed consciousness, speech
deficits (usually aphasia), sensory and cognitive
impairments, involuntary movements, and vision
problems.
 Is
there any treatment?
Till now, there was no
cure for Moyamoya disease and treatment was symptomatic
and supportive till I have carried out genetic
engineering work on Moyamoya.. Lot of theories in terms
of treatment- medical and surgical have been postulated
such as use of aspirin, anticoagulant like Warfarin and
surgeries of various types such as anastomosis between
extra and intracranial arteries beyond the blockages,
multiple bar holes to generate new arteries etc. Idea is
to provide maximum blood supply and Oxygen to brain
tissue. This process of treatment miserably fails
because in presence of excessive accumulation of
intracellular Calcium, oxygen cannot enter into
mitochondria leading to inadequate ATP formation. It is
one of the many presentation of Baruah syndrome which I
have described long time ago. This syndrome is so
dangerous, that it affects entire arterial system
causing functional dysfunction of sodium pump.
A four years old boy
was presented with the history of repetitive transient
fainting attacks since last three months, but parents
have noticed that movement of his left leg was not
normal. His playing activities had reduced due to
excessive tiredness and he tends to fall. They have been
to Apollo and several hospitals, and diagnosed by MRI of
brain that the child is suffering from Moyamoya disease
and there is no curative treatment so far on this planet
and death is certain soon. The parents were helpless and
waiting to see the sufferings of the child. They came to
me for genetic engineering treatment and as this is
genetic disorder, they thought that this will help them
out.
Master Manas Das -Four
years old boy suffering from Moyamoya disease,
recannalization of both internal carotid arteries were
done byBaruah applied human genetic engineering.
I have developed the
technique to diagnose Baruah syndrome bio-chemically and
by use of Doppler flow studies. Flow velocity and
irregularities in flow during systole gives the exact
idea of pattern of intracranial blood flow . The
observation is made by placing the probe at the
bifurcation of common carotid artery. This piece of
studies is extremely important to confirm post-genetic
engineering progress.
His total blood
chemistry analysis had confirmed that he is suffering
from Baruah Syndrome with excessive accumulation of
intracellular Calcium and functional dysfunction of
sodium pump.
MRI angiography had
confirmed bilateral intracranial stenosis of internal
carotid arteries with sufficient collateral circulation.
Pre-treatment colour
Doppler flow studies of internal carotid arteries, right
and left subclavian arteries shows-
irregular velocities with
high and low systolic flow in right subclavian and right
axillary arteries
decrease flow in
right & left internal carotid artery suggestive of
distal stenosis.
Patient’s mistaken DNA
was decoded by injecting Baruah biological molecules on
July 2007 and his post- genetic engineering progress was
studied after one week. We have observed the remarkable
improvement with following results-
Disappearance of Baruah
syndrome
Post-treatment colour Doppler flow studies revealed-
Intracranial flow
of internal carotid arteries is improved and relatively
non-obstructive.
Irregularities of
right subclavian artery & axillary artery pulsation
disappeared
This result has
correlated accurately with biochemical and physical
improvement of the child. The child is now more playful,
pink, walking and running normally.
Conclusion
:
We have got more
helpless patients suffering from Moyamoya disease where
genetic engineering work will bring similar remarkable
results and progress. Lot of painstaking research work
was carried out by us to cure ‘Moyamoya.’ disease.
Our research work has
suggested that the word "Moyamoya" is a misnomar.
Japanese researchers confined their studies to
intracranial collaterals- that is puff of smoke only.
Our
discoveries :
One can argue that in
presence of excessive collaterals providing sufficient
blood supply to brain, why the transient ischemic
attacks are repeated leading to atrophy of brain and
premature death? This problem was not understood by
Japanese researchers.
It is primarily
excessive accumulation of subcellular calcium where
mitochondria are unable to accommodate adequate quantity
of oxygen as a fuel to synthesize sufficient quantity of
ATP. Therefore, it has been strongly proven that
although, there is a surgical procedure undertaken
between extra- and intra-cranial arteries to provide
adequate amount of blood to the brain, it has never
worked as this procedure cannot remove excessively
accumulated subcellular Calcium to provide space for
Oxygen. Our Genetic engineering using Baruah biological
molecules removes this subcellular excessive Calcium and
provides oxygen adequately and uniformly to the brain as
a whole to remove repeated transient ischemic attack
permanently.
Again, we have observed that the child
having Moyamoya- also having reduced forward blood flow
through both subclavian arteries, so it means that
Japanese researchers’ work did confine strictly within
the cranium. They failed to understand that this could
be a generalized pathological abnormalities caused by
accumulation of excessive intracellular Calcium. I have
named this disease not as "Moyamoya’, but "Dhuan-Dhuan"
as one of the several manifestation of Baruah syndrome.
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Copyright© DR Dhani Ram Baruah Heart City2007
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