Systemic Lupus Erythematosus (SLE) is a chronic potentially fatal autoimmune disease. SLE is a complex disorder resulting from the production of antibodies that attack the DNA and proteins within healthy cells and the generation of circulating immune complexes. The complications from this affect multiple organs and are potentially life-threatening.

Joints, skin, kidney, brain, and membranes of the lung, heart and gastro-intestinal tract are the major organs clinically affected in SLE patients. The symptoms are often vague, can be mild or severe and are often unrelated to laboratory tests. A patient can have many lupus symptoms in a lifetime. Women and non-Caucasians are disproportionately affected and SLE is most common in women of child-bearing age although it has been reported in all ages. The incidence is about 1 in 200 people in America. Among children, SLE occurs three times more commonly in females than in males. In the 60% of SLE patients who experience onset between puberty and the fourth decade of life, the female to male ratio is 9:1. The disorder is three times more common in African American blacks than American Caucasians and more common in Asians.The cause of SLE was said to be unknown, however our research work has suggested that it is of genetic origin as we have cured SLE patient with Dr.Baruah’s genetic engineering. It was thought that hormonal and /or environmental factors are few factors affecting SLE, but it is not true. As corrective therapies such as hormone replacement or supportive treatment do not cure SLE.

          Many researchers had suspected that it is a genetic mutation that disrupts the body’s waste disposal mechanism in cells. SLE is caused by a hyperactive immune system that attacks a person’s own protein recognising it as a foreign material. One reason for this is poor adrenal function. Adrenal steroids modulate the immune system. When there is insufficient steroid levels, the immune system goes haywire. Whatever hypotheis of possible causes have been postulated in the past and present, no one was or is able to cure SLE, till we have discovered the Baruah biological molecules which intercepts the cells destructive autoimmune pathway.

          Fatigue on light exertion, light sensitivity, skin rash, ulcers in mouth specially on soft palate and on nasal septum, susceptibility to infection with slow recovery, muscle pain, mild or high fever, sore throat, numbness, headache, tingling or burning sensation in extremities, joint pain/ stiffness/swelling, chest pain, atherosclerosis, respiratory distress, uro-genital infections, nephropathy, anemia, low white cell/platelet counts and several other disorders are the usual symptoms.

          Diagnosing SLE can be a difficult and slow process. It may take months or even years for doctors to diagnose this complex disease accurately. A tentative diagnosis can be made through examining a patient’s medical history and performing a physical examination and screening tests (positive SLE-ANA >40). Once SLE is suspected, additional tests are valuable to confirm or rule it out. Elevated ESR or high levels of ANA are the common laboratory test indicative of SLE.

          The most useful test is to identify certain autoantibodies often present in the blood of SLE patients. For example, the antinuclear antibody (ANA) test is commonly used to look for autoantibodies that react against components of the nucleus of the patient’s own cells. In addition, there are blood tests for individual types of autoantibodies that are more specific for SLE.

          Treatment for SLE in medical science is not specific and not available, where it is treated with steroids, certain hormonal therapies, diet, plant steroids, immunosuppressive drugs and timely treatment for any infection and so on. But 100% cure is not yet known.

          Since last 7 years, a 25 years old girl, was suffering from SLE She was treated by local doctors and found that she was suffering from incurable disease which cannot be diagnosed. They referred her to CMCH,Vellore.. They diagnosed that , she was suffering from SLE. They treated her with conventional way , that is with cortisone, cyclophosphamide, methotraxate. These drugs are usually used in cancer or as immunosuppressive drugs in transplant. She developed tuberculosis of optic nerve, due to which she became blind. Her tuberculosis was treated for one year, but her blindness did not get cured. She even could not see the motor car, not to speak about pictures in television. She gained weight. Her blood pressure went up and she got pain all over the body. Slowly, she developed signs and symptoms of renal failure. Renal failure is one of the complication of SLE, due which patient dies. Her menstruation stopped and she gained weight from 45 kg to 85Kgs within a period of 7 years till she attended our clinic, she became dis-figured. Her parents had spent almost 1.3million rupees for her treatment. They lost hopes for her life as her signs and symptoms were continued to be getting worst.

                They came to know about my new technique of treating the rarest of the rare diseases with genetic engineering using Baruah biological molecules. She got admitted in my Institute at Sonapur 14weeks ago. As a baseline for pre-treatment, SLE antibody tests were carried out in Micro Diagnostic laboratory, Guwahati and biochemistry in our Institute. Her diseased genes were engineered by using Baruah biological molecules and introduced intravenously. Prior to starting Baruah therapy, her all the medication which was prescribed earlier was stopped.

                     After the first injection, she felt better and she was able to see with her eyes, even she could see the pictures on television. Her vomiting was stopped, her weight was reduced by 6 kgs within 2 weeks. But her headache was continued with less intensity and hypertension was unable to come down to normal level.. We continued her treatment.further

          Her post-treatment pathological antibody tests was carried out by Dr. Rajeeb Bhuyan, which were negative for SLE. Her mental condition has improved. Her kidney function becomes normal after two weeks of genetic engineering treatment.

                    She has no symptoms and signs of SLE. Her blood pressure has become normal with disappearance of headache. She reduced weight by 16 kgs. She got her regular menstruation back after 14 weeks.

                    Since 1995, a 23 years old girl from hyderabad, was suffering from systemic lupus erythromatosus (SLE) with thrombo-cytopenia & anemia. She was treated by local doctors with conventional way , that is with methyl prednisolone, Azathaiprine alongwith repeated transfusions of packed cells, platelet rich plasma etc. . These drugs are usually used in cancer or as immunosuppressive drugs in transplant. Day by day, her condition was getting worst & worst inspite of getting conventional therapy. She developed pain in her abdominal portion, which was not relieved by any pain killer. Her parents had spent several lakhs of rupees for her treatment. They lost hopes for her life as her signs and symptoms were continued to be getting worst.

                    As she was an Engineer, through internet, she came to know about my new technique of treating the rarest of the rare diseases with genetic engineering using Baruah biological molecules. She got admitted in my Institute at Sonapur 1week ago. As a baseline for pre-treatment, SLE antibody tests were carried out in Micro Diagnostic laboratory, Guwahati and biochemistry in our Institute. Her diseased genes were engineered by using Baruah biological molecules and introduced intravenously. Prior to starting Baruah therapy, her all the medication which was prescribed earlier was stopped.

          After the first injection, she felt better and her pain was relieved. Her hemoglobin was improved. Her post-treatment pathological antibody tests was carried out by Dr. Rajeeb Bhuyan, which were negative for SLE.

                    SLE, an autoimmune disease like arthritis, for which there is no cure and majority of patients die prematurely. Now onwards, our genetic engineering has ruled out the premature death of the patients suffering from SLE and will be fully cured with Baruah biological molecules, which intercepts the pathways of formation of new immune complex which circulates in the body destroying the cells.

          Although, the pathway of forming new destructive immune complex has been stopped, but the already formed immune complexes continue to circulate, which takes 8-10 weeks to disappear.