UNFOLDING THE MYSTERIES OF GENETIC SCIENCES IN INCURABLE DISEASES LIKE CORONARY ARTERY DISEASES, CANCER, & RAREST OF THE RARE DISEASES LIKE MOYAMOYA, SLE, TAKAYASU ETC.

 Abstract :-

            A complex congenital heart disease such as transposition of great arteries (TGA) with or without ASD or VSD is not known to be uncommon. The child is borne with TGA with or without ASD or VSD, the common cause of blue babies is known to all clinicians. The child borne with TGA without ASD or VSD and without having patency of ductus aortus has incidence of survival of more than few hours, which is very remote. Atrial septostomy was a standard procedure for long run survival. Infusion of prostaglandin is used to keep the PDA patency as a short term therapy, is also a standard medical practice before taking the patient for corrective surgical procedure. Mustard procedure was a standard one at atrial level which was changed to Senning procedure in different stages of childhood. Switch surgical procedure had started some years ago and it is now a standard surgical procedure of TGA and this should be done within 72 hours after child is borne to obtain good results. However, late complications like stenosis of pulmonary artery and aorta were reported. (TGA-Shilpajyoti Kashyap treated at the age of 9 with Baruah Biological molecules. Her shunt was reversed with asymptomatic with Baruah applied human genetic engineering treatment since 2002.)

 Introduction:-

           Cyanosis of lips, finger nails, toes, breathlessness, chronic chest infection with cough and cold and fever, retardation of mental and physical growth, low exercise tolerance are the common features of TGA with VSD in later days of childhood. This group of patients do not usually survive beyond their teenage as reported. At this stage, heart-lung transplant has become a standard surgical procedure

 History:-

        Eleven year old girl was brought by parents with following congenital anomaly to our clinic in month of July 2003. She attended two another hospitals where she was sent back home saying that there is no surgical or medical treatment available at this stage. The child had the following signs, symptoms and diagnosis.

          Her parents were agreed to go for heart-lung transplant using pig as a donor. However, as a first step, we have treated her with Baruah biological molecules and treatment was started from July 5th, 2003.

 Results:-

          Three days later, her chest infection and congestion began to disappear and breathlessness was reduced . Blueness of lips, toes and finger nails began to disappear and became pink.  Six days later, she regained her appetite and food intake was increased. We continued the same treatment and on 29th July, post-treatment echo with colour Doppler echocardiography was done.

     The following findings were observed:-

 Discussion:

                    Our organic compounds from medicinal plants have reduced the higher pressure of morphological right ventricle which is functional left ventricle allowing shunt to reverse where ratio of deoxygenated and oxygenated blood was changed resulting disappearance of cyanosis, improvement of liver function and exercise tolerance. Patients with complex congenital heart disease such as TGA with VSD do not have incidence of long term survival. They have a continuous problems like chest infection, mental retardation, stunted growth, not doing well in the school, breathlessness, and not gaining weight. Heart –lung transplant is the only surgical procedure can be undertaken for these patients with low incidence of survival. High Pulmonary pressure is the major problem. Reduction of PA pressure with reversal of shunt are not known till today treated with conventional therapy such as diuretics, digitalis. This is probably for the first time treated successfully with isolated plant organic compounds. However, long-term results are yet to be seen with this therapy.