Unfortunately, all genetic research ended up with publication, but no application. Genetic scientist are found to be more theoretical and we have not observed its application so far applying it to human race to cure the dreaded diseases like coronary artery disease and cancer. It is not digestible fact if the genetic engineering has applied to cure the dreaded disease like CAD then one can ask a question, why this disease has become an epidemic on this planet and why wrong treatment like coronary artery bypass surgery, stenting, angioplasty, are undertaken? Therefore, it has been proven that till now, not a single step has gone ahead in genetic sciences to find out the genes responsible for causing the coronary artery disease, hypertension, diabetes, cancer etc. and how to engineer those mistaken genes to cure these diseases permanently. Till now, so far we have observed the results of genetics for curing various diseases on this planet is zero.

          Splicing is the process where intron & exon alignment has to play an important role which will express normally in disease form during the process of translation. Intron goes into nucleus with DNA and exon follow m-RNA at the level of maturity in cytoplasm and this is the time, genetic encoding takes place and accordingly, it is expressed when the conditions are favourable. In some cases, it remains dormant, not expressed, when environment is not favourable for genetic code. Favourable & unfavourable conditions are being described in terms of degree of active immune system, if the immune system is not very active, that means conditions are favourable for that expression of the disease. During our experimentation, we were surprised to see how mutation of these particular genes are seen and how it is been de-mutated after injecting the Baruah biological molecules. Baruah biological molecules are subsequently used as tools for demutation of genes which are isolated from plants of north eastern region of India. We have described in earlier chapters how we have carried out the experimentation ex-vivo & in vivo with these molecules, We found that Baruah biological molecules are tools on this planet to cure these diseases permanently. The details of the genetic procedures of genetic engineering are given in following chapters. In the past, there is none in the genetic science who has carried out this type of work.. Had there been, I would not have taken up time consuming, laborious & expensive genetic sciences for my research being myself a cardiac surgeon.

These conditions have been correlated with clinical situation where following findings are obtained:-

         Our animal experiments have suggested that mutation for heart diseases is not under the influence of change of life style, and food habits. It is due to change of mental status, stress & strain. This happens at the age between 13-16, when human physiology changes, leading to pathological conditions under certain environment, those who are under change of mental status and degree of mental stress. These two conditions have greater effect on mutations which get expressed in diseased form in about 15-20years bringing the errors, reversing the metabolic pathways and ultimately expressed in diseased form of respective type.

          These diseases can be stopped by de-mutation, thereby decoding the mistaken gene, that is genotypic effect will be expressed in phenotypic disease-free form permanently.

          We are capable of preventing these diseases by using Baruah biological molecules which stops initiation of mutation at the age between 13 and 16 and question of decoding of mistaken genes does not arise.. Therefore, I conclude that coronary artery disease can be eradicated completely by using the method of Baruah applied human genetic engineering, where Baruah biological molecules can be used as tools.