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Effect of edible medicinal plant extracts on albino pigs

fed with highly atherogenic diet

     Abstract

              We had selected medicinal plants which are used by local tribes as vegetable or for medicinal use. Though we have studied the safety of these edible medicinal plants in animals,  we were more curious to study its efficacy in patients suffering from coronary artery disease (CAD). We have fed highly atherogenic diet to 42 human volunteers.

               Aim of the trial was to increase their serum lipids with imbalance electrolytes simulating the condition of CAD patients and to study the efficacy of our edible medicinal plants to cure CAD. The volunteers were divided into 7 groups. Each group was fed with highly atherogenic diet of pure vegetarian, non-vegetarian and mixed type. Alcohol was given  in  various quantities to observe the  changes in serum lipid content. Their weight, blood pressure and heart rate  were measured before the evaluation and total blood chemistry was estimated. The same was repeated each week during the total period of evaluation. The raised lipid profile is observed in pure vegetarian and non-vegetarian groups. The biological molecules isolated from edible medicinal plants reduces its LDL- cholesterol with increase in HDL-cholesterol. and results are presented here.   

      Introduction

           Till now, many hypothesis have been put forward to find out the causes of ischemic heart disease such as Type A personality, high fatty diet, stress, strain, hypertension, smoking, excessive alcohol consumption, diabetes etc.

           We have undertaken painstaking  research work to find out the herbs or medicinal plants to prevent coronary artery disease. As described in our previous paper, we have selected 3 medicinal plants, which help in reduction of risk /atherogenic factors such as high blood pressure, diabetes, triglycerides and cholesterol levels, LDL-Cholesterol and increase in preventing factor such as HDL-Cholesterol with improved liver and kidney function.

         We have fed highly atherogenic diet to human volunteers divided in 4 groups according to their diet for 2 weeks each. Their glucose, lipid profile, liver and cardiac enzymes were monitored before feeding the particular diet, after two weeks of feeding the diet, and thirdly after treating them with respective biological molecules isolated from edible medicinal plants.

The Results are Presented in the Present Paper with Analysis.

Methods

       The 42 human volunteers were divided into 4 groups according to the diet given to them. Each group was fed with highly atherogenic diet of  non-vegetarian (either pork/beef-) with and without alcohol and pure vegetarian type as described below..

Group I- Non-Veg.(with beef)- Human volunteers-12 nos

               Breakfast                                Lunch                                              Dinner  

              Boiled eggs (2nos)               Boiled Rice (250gm)                        Boiled Rice (250gm)

              White Bread (2pcs)               Pulses (250gm)                                    Beef (500gm)

              Butter (50gm)                          Ghee (50gm)                                      Ghee (50gm)

              Milk (150CC)                           Milk (150CC)                                      Milk (150CC)

Group II- Non-Veg. (with pork with alcohol and without alcohol)

              Breakfast                                   Lunch                                           Dinner           

             Boiled eggs (2nos)               Boiled Rice (250gm)                        Boiled Rice (250gm)

             White Bread (2pcs)                Pulses (250gm)                                    Pork (500gm)

             Butter (50gm)                         Ghee (50gm)                                       Ghee (50gm)

             Milk (150CC)                          Milk (150CC)                                       Milk (150CC)

         This group is divided into two subgroups-one is consumed 750CC alcohol each and second group is kept without alcohol, instead given 150CC cream with each meal.                                           Human volunteers -With alcohol-18nos Without alcohol +with cream-6nos.

Group III- Vegetarian (Human volunteers- 6 nos.)

             Breakfast                                     Lunch                                           Dinner  

             Rasgulla (2nos)                        Boiled Rice (250gm)                     Boiled Rice (250gm)

             White Bread (2nos)                     Pulses (250gm)                                   Beef (500gm)

             Butter (50gm)                               Ghee (50gm)                                       Ghee (50gm)

             Milk (150CC)                                Milk (150CC)                                      Milk (150CC)

             Fried potatoes(100gm)                   Fried Potatoes(100gm)

       The above diet was continued for two weeks. The above 4 groups were further divided into 7 subgroups (6 human volunteers in each group) according to the type of medicinal plant extract given for feeding. 30CC extracts of medicinal plants alpha, beta and gamma and its various combinations were fed to different group while continuing the same diet for 2 weeks.   Their serum glucose, lipid profile, electrolytes and liver & cardiac enzymes were analysed with the methods described earlier and following results are obtained.

Results and observations:-

Control- (before starting the highly atherogenic diet)

 

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