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Introduction.
Mysteries in
genetic sciences.
What is
coronary artery disease?
Misconceptions in cardio-vascular
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Foundation
on which building of Baruah Applied Human.
Revolution in medical sciences rocked by
Dr.D.R. Baruah,FRCSGlas.
Unfolding the
mysteries in human genetic sciences.
Mysteries in
human genetic sciences.
How does the
mutation expresses in particular disease form?
Selection of
patients for gene analysis
Eradication of
heart disease & rarest of the rare diseases- Human genetic studies
through sequencing of m-RNA.
Signal
Transduction plays a major role during pre-bypass and post-bypass
events.
How bypass
surgery triggers signal transduction & phenotypically expressed.
Mutation
Selection of
genes causing heart & other diseases.
Hypoxia,
reactive oxygen species, intracellular calcium & Baruah syndrome.
Re-sequencing
of the following genes to identify the mysteries.
First time on
this planet– Genovac.
Baruah applied
human genetic engineering- a choice of treatment for Cancer.
TGA-A New
Method of Treatment of Complex Congenital Heart Disease.
Endocardial Cushion defect.
Genetic
Engineering–To cure the rarest of the rare autoimmune.
First time on
the Planet–Manifestation of Baruah Syndrome–Moyamoya
The rarest of
the rare genetic disorder–Takayasu.
Isolated
congenital Right Ventricular Hypertrophy.
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Applied Human Genetic Engineering - Vol.II |
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Isolated congenital Right Ventricular
Hypertrophy is the rarest of the rare
condition
Treated successfully
with Baruah genetic engineering
 I ntroduction-
Left ventricular (LV) hypertrophy is
known to be not uncommon in children due to congenital
aortic valve stenosis, either in bicuspid or tricuspid
aortic valve. In case of bicuspid aortic valve, outflow
orifice area of aortic valve becomes inadequate leading
to LV hypertrophy and in case of tricuspid aortic valve,
the valve leaflets failed to separate from each other
resulting smaller outflow orifice area, which gives rise
to left ventricular hypertrophy. In both cases, although
the pathology is somewhat different, but results are
similar. Isolated right ventricular (RV) hypertrophy is
rarest of the rare condition in children In this
condition, structurally pulmonary valve could be either
tricuspid or bicuspid, leading to smaller outflow
orifice area resulting inadequate pulmonary perfusion.
RV wall thickness is increased , so is the
interventricular septum leads to remarkable reduction of
RV cavity resulting inadequate ejection or stroke
volume. Usually, this condition is corrected by surgical
means without zero mortality and morbidity. We have
treated this congenital anomaly successfully in a female
patient of 16 years of age with genetic engineering
using Baruah biological molecules.
A
brief - Patient’s history-
 In November 2006, a female patient of
16 years of age was admitted in our clinic with
complains of fever, cough, tiredness and breathlessness
on minimum exertion. Since last 7 years, she was treated
elsewhere withot getting any relief. But her chest x-ray
does not reveal any severe pulmonary infection and
tuberculosis. (Pulmonary tuberculosis is not uncommon in
place where patient lives). Cardiac enlargement due to
right ventricular hypertrophy was well observed  in
X-ray. Echocardiogram had suggested that patient has
tricuspid pulmonary valve with reduced orifice area
having right ventricular wall thickness of 17.34mm, so
is the interventricular septum. (Fig.1). RV perfusion
pressure was measured to be 74mm Hg, which is found to
just above the double of normal.
Axomi
Das
(A 16 years old
girl was suffering from right ventricular hypertrophy.
Hypertrophy was reduced with Baruah biological
molecules.)
(
Fig.1 )
Genetic engineering using Baruah
biological molecules-
Patient was treated with Baruah
biological molecules intravenously followed by oral
therapy for a period of one year. In initial period,
patients all symptoms had disappeared and she continued
to be kept physically very well.
Post-treatment follow up after 1year-
One year later repeat colour Doppler
echocardiogram has suggested her RV wall thickness is
reduced by 3.0mm resulting increase in the size of right
ventricular cavity with improved stroke volume.
Discussion-
Right ventricular hypertrophy is not
a common disorder, which is usually treated surgically
by repairing pulmonary valve and occasionally, it
requires replacement with artificial heart valve.
However, morbidity and mortality are not uncommon., Use
of genetic engineering to treat this condition is found
to be unique and first in cardio-vascular sciences.
During the process of genetic
engineering Baruah Biological molecules down regulate
the overexpressed m-RNA expressed diseased genes
resulting hypertrophied muscles, which looses their
elasticity.and this process continues till it changes
the anatomical configuration of right ventricle allowing
right ventricle to perform physiologically. RV perfusion
pressure has come down to 41mm Hg., which is near
normal.
Conclusion-
In the history of cardio-vascular sciences, treatment
of hypertrophied right ventricle has been treated with
genetic engineering for the first time. It is usually
corrected surgically or some of medical treatment with
equivocal success rate. Hundred percent success rate is
achieved by using Baruah genetic engineering which has
proven that conventional surgical or medical therapy are
not only un-necessary, but destructive.
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